Pagolone is a specific GABA (Gamma-aminobutyric acid) receptor modulator that can reduce stuttering. Pagolone is a novel cyclopyrrolone that acts as a partial GABA (A) receptor agonist.

CHEMICAL PROPERTIES

PRODUCT USAGE

Pagoclone is a non-benzodiazepine anxiolytic compound belonging to the cyclopyrrolone family. As a selective GABA-A receptor partial agonist, its primary pharmaceutical application has been the focus of clinical research for treating generalized anxiety disorder (GAD) and panic disorders. Unlike traditional benzodiazepines, pagoclone is designed to provide anti-anxiety effects with significantly reduced sedative and amnestic side effects. Furthermore, it has gained international attention for its potential application in treating persistent developmental stuttering, with clinical trials exploring its ability to improve speech fluency. In the research sector, it serves as a critical reference standard for studying receptor subtype selectivity and the development of next-generation social ligands.